Frazier and Mosteller assert that medical research could be improved by a move toward larger, simpler clinical trials of medical treatments. Currently, researchers collect far more background information on patients than is strictly required for their trials—substantially more than hospitals collect—thereby escalating costs of data collection, storage, and analysis. Although limiting information collection could increase the risk that researchers will overlook facts relevant to a study, Frazier and Mosteller contend that such risk, never entirely eliminable from research, would still be small in most studies. Only in research on entirely new treatments are new and unexpected variables likely to arise.

Frazier and Mosteller propose not only that researchers limit data collection on individual patients but also that researchers enroll more patients in clinical trials, thereby obtaining a more representative sample of the total population with the disease under study. Often researchers restrict study participation to patients who have no ailments besides those being studied. A treatment judged successful under these ideal conditions can then be evaluated under normal conditions. Broadening the range of trial participants, Frazier and Mosteller suggest, would enable researchers to evaluate a treatment's efficacy for diverse patients under various conditions and to evaluate its effectiveness for different patient subgroups. For example, the value of a treatment for a progressive disease may vary according to a patient's stage of disease. Patients' ages may also affect a treatment's efficacy.

The passage is primarily concerned with

identifying two practices in medical research that may affect the accuracy of clinical trials

describing aspects of medical research that tend to drive up costs

evaluating an analysis of certain shortcomings of current medical research practices

describing proposed changes to the ways in which clinical trials are conducted

explaining how medical researchers have traditionally conducted clinical trials and how such trials are likely to change



1. F&M提议:更简单的医疗诊治


2. 提议的具体内容:

a.  减少信息提取。

b. 扩大样本。优点:考虑更多情况,使用于更多病人群体










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